Echinoid Is a Component of Adherens Junctions That Cooperates with DE-Cadherin to Mediate Cell Adhesion
نویسندگان
چکیده
منابع مشابه
INTRODUCTION Cadherins impart strong cell-to-cell adhesion that nucleates the assembly of adherens junctions. Initial adhesion events organize a multi-protein, cytoskeletal complex at adhesion sites
Cadherins impart strong cell-to-cell adhesion that nucleates the assembly of adherens junctions. Initial adhesion events organize a multi-protein, cytoskeletal complex at adhesion sites (Adams et al., 1996, 1998; McNeill et al., 1993). This adhesion complex grows rapidly, organizes the lateral plasma membrane, and helps generate polarized distributions of plasma membrane proteins (Yeaman et al....
متن کاملPolymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
Polymorphonuclear leukocytes (PMN) infiltration into tissues is frequently accompanied by increase in vascular permeability. This suggests that PMN adhesion and transmigration could trigger modifications in the architecture of endothelial cell-to-cell junctions. In the present paper, using indirect immunofluorescence, we found that PMN adhesion to tumor necrosis factor-activated endothelial cel...
متن کاملCell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells.
The first steps of invasion and metastasis include the dissociation of adherens junctions and the induction of migratory phenotype, through a program that resembles epithelial-mesenchymal transition (EMT). The L1 cell adhesion molecule, which is normally found primarily in the brain, was recently shown to be expressed in different types of cancer and to have tumor-promoting activity. We now fin...
متن کاملMyofibroblast development is characterized by specific cell-cell adherens junctions.
Myofibroblasts of wound granulation tissue, in contrast to dermal fibroblasts, join stress fibers at sites of cadherin-type intercellular adherens junctions (AJs). However, the function of myofibroblast AJs, their molecular composition, and the mechanisms of their formation are largely unknown. We demonstrate that fibroblasts change cadherin expression from N-cadherin in early wounds to OB-cadh...
متن کاملModulation of cell-cell adherens junctions by surface clustering of the N-cadherin cytoplasmic tail.
Cadherins mediate the formation of cell-cell adherens junctions (AJ) by homophilic interactions through their extracellular domains as well as by interacting with the actin cytoskeleton via their cytoplasmic portions. Cadherin clustering initiates cytoplasmic signaling that results in the assembly of structural components into cell-cell AJ. To elucidate the function of the cytoplasmic tail of c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2005
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2005.03.015